IKB protein
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Function
- IkB binds to the p65 subunit of NF-kappa B, inhibiting transcriptional activity of NF-kappa B by retaining it in the cytoplasm
- activation of NF-kappa B with translocation to the nucleus appears to require phosphorylation-dependent proteolysis of IkB
Structure
- IkB proteins contain 5-7 ankyrin repeat domains which interact with Rel regions
More general terms
More specific terms
- NF-kappa B inhibitor alpha; IKB-alpha; MHC enhancer-binding protein MAD3; NF-kappa-B inhibitor alpha; I-kappa-B-alpha; IkappaBalpha; IkB-alpha; NFKBIA; IKBA (MAD3, NFKBI)
- NF-kappa-B inhibitor beta; NF-kappa-BIB; I-kappa-B-beta; IkappaBbeta; IkB-beta; IkB-B; thyroid receptor-interacting protein 9; TRIP-9; TR-interacting protein 9 (NFKBIB, IKBB, TRIP9)
- NF-kappaB inhibitor epsilon; NF-kappa-BIE; I-kappa-B-epsilon; IkappaBepsilon; IkB-epsilon; IkB-E (NFKBIE, IKBE)
Additional terms
References
- ↑ Thompson CC, Brown TA, McKnight SL. Convergence of Ets- and notch-related structural motifs in a heteromeric DNA binding complex. Science. 1991 Aug 16;253(5021):762-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1876833
- ↑ Brown K, Gerstberger S, Carlson L, Franzoso G, Siebenlist U. Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation. Science. 1995 Mar 10;267(5203):1485-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7878466
- ↑ Baeuerle PA, Baltimore D. NF-kappa B: ten years after. Cell. 1996 Oct 4;87(1):13-20. No abstract available. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8858144