F-box/WD repeat-containing protein 11; F-box/WD repeat-containing protein 1B; F-box & WD repeats protein beta-TrCP2; homologous to Slimb protein; HOS (FBXW11, BTRCP2, FBW1B, FBXW1B, KIAA0696)

Function

• substrate recognition component of a SCF complex
• interacts with BTRC
• interacts with phosphorylated ubiquitination substrates CTNNB1, NFKBIA, IFNAR1; the interaction requires phosphorylation of the 2 Ser in the substrates' destruction motif D-S-G-X(2,3,4)-S

Structure

• contains 1 F-box domain
• contains 7 WD repeats

Compartment

cytoplasm (putative)

Alternative splicing

named isoforms=3; C, A, B

More general terms

• F-box & WD-repeat protein

Component of

• SCF-type E3 ligase complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23291
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23291
• OMIM: https://mirror.omim.org/entry/605651
• UniProt: http://www.uniprot.org/uniprot/Q9UKB1.html