interferon-alpha/beta receptor alpha chain; IFN-alpha-REC (IFNAR1, IFNAR)

Function

• receptor for IFN-alpha & IFN-beta
• binding to type 1 IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins & IFNR alpha- & IFNR beta-subunits themselves
• phosphorylated on Tyr by TYK2 tyrosine kinase

Structure

• belongs to the type 2 cytokine receptor family
• contains 3 fibronectin F3 modules

Compartment

isoform 1: membrane

Alternative splicing

named isoforms=3

Expression

• IFN receptors are present in all tissues & even on the surface of most IFN-resistant cells
• isoform 1, isoform 2 & isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266S
• isoform 2 & isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R
• isoform 1 is not expressed in U266R

More general terms

• interferon receptor
• glycoprotein
• phosphoprotein

Additional terms

• interferon beta; IFN-beta; fibroblast interferon (IFNB1, IFB, IFNB)
• interferon [IFN]-alpha

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3454
• OMIM: https://mirror.omim.org/entry/107450
• UniProt: http://www.uniprot.org/uniprot/P17181.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3454