activating transcription factor-4; cyclic AMP-dependent transcription factor ATF-4; DNA-binding protein TAXREB67; cyclic AMP response element-binding protein 2; CREB2 (ATF4, TXREB)

Function

• transcriptional activator
• binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral & cellular promoters
• binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I
• interacts with the C-terminal region of GABBR1 via the leucine zipper of its C-terminal bZIP domain
• interacts with the C-terminal region of GABBR2 (putative)
• binds DNA as a homodimer or heterodimer
• interacts with the N-terminal region of CEP290

Structure

• belongs to the bZIP family
• contains 1 bZIP domain

Compartment

• cytoplasm, cell membrane, nucleus
• colocalizes with GABBR1 in hippocampal neuron dendritic membranes (putative)

Comparative biology

• ortholog of yeast GCN-4
• elevation of ATF4 expression, at least in liver, seems to be a shared feature of diets, drugs, genes, & developmental alterations that extend maximum lifespan in mice

More general terms

• activating transcription factor

Database

• UniProt: http://www.uniprot.org/uniprot/P18848.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:468
• OMIM: https://mirror.omim.org/entry/604064
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=468