RING-box protein 1; Rbx1; regulator of cullins 1; RING finger protein 75; protein ZYP (RBX1 RNF75 ROC1)

^[1]^[2]

Function

ubiquitin conjugation, 3rd step
neddylation of CUL1, CUL2
component of the SCF complex
component of CUL7-RBX1-SKP1-FBXW8 complex
component of the CBC(VHL) (CUL2-elonging BC-VHL) E3 ubiquitin ligase complex
through the RING-type Zn+2 finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex & brings it into close proximity to the substrate
probably also stimulates CDC34 autoubiquitination
may be required for histone H3 & histone H4 ubiquitination in response to ultraviolet & for subsequent DNA repair
promotes neddylation of CUL1, CUL2, CUL4 & CUL4 via its interaction with UBE2M
part of a SCF-like complex consisting of CUL7, RBX1, SKP1 & FBXW8
part of CBC(VHL) complexes with elongin BC complex (TCEB1 & TCEB2), CUL2 or CUL5 & VHL
part of multisubunit E3 ubiquitin ligase complexes with elongin BC complex (TCEB1 & TCEB2), CUL2 & MED8;
elongin BC complex (TCEB1 & TCEB2), CUL5 & MUF1
part of multisubunit complexes with elongin BC complex (TCEB1 & TCEB2), elongin A/TCEB3 or SOCS1 or WSB1 & CUL5
interacts directly with CUL1 & probably also with CUL2, CUL3, CUL4A, CUL4B, CUL5 & CUL7
probably interacts with CDC34
interacts with COPS6
component of the DCX DET1-COP1 ubiquitin ligase complex
part of an E3 ligase complex composed of RBX1, DDB1, DDB2 & CUL4A or CUL4B
interacts with UBE2M

the RING-type Zn+2 finger domain is essential for ubiquitin ligase activity; it coordinates an additional third Zn+2
belongs to the RING-box family
contains 1 RING-type Zn+2 finger

widely expressed