WD repeat & SOCS box-containing protein 1; WSB-1; SOCS box-containing WD protein SWiP-1 (WSB1, SWIP1)

Function

• probable substrate-recognition component of an elongin-Cullin-SOCS-box protein (ECS) E3 igase complex which mediates the ubiquitination & subsequent proteasomal degradation of target proteins
• recognizes type II iodothyronine deiodinase/DIO2
• confers constitutive instability to HIPK2 through proteasomal degradation
• protein modification; protein ubiquitination
• interacts with DIO2
• component of probable ECS(WSB1) E3 ubiquitin ligase complex
• interacts with CUL5, RNF7, TCEB1 & TCEB2
• binds to HIPK2 through WD40 repeats

Structure

• the SOCS box domain mediates the interaction with the elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (putative)
• contains 1 SOCS box domain
• contains 6 WD repeats

Alternative splicing

named isoforms=3

More general terms

• WD repeat protein family

Additional terms

• SOCS box domain
• WD repeat

Component of

• ECS(WSB1) complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26118
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:26118
• OMIM: https://mirror.omim.org/entry/610091
• UniProt: http://www.uniprot.org/uniprot/Q9Y6I7.html