Cullin-5; CUL-5; vasopressin-activated Ca+2-mobilizing receptor 1; VACM-1 (CUL5, VACM1)

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Function

core component of multiple SCF-like ECS complex(es) (elongin-Cullin 2/5-SOCS-box protein complex), E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination & subsequent proteasomal degradation of target proteins
as a scaffold protein may contribute to catalysis through positioning of substrate & ubiquitin-conjugating enzyme
functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component
ECS(SOCS1) seems to direct ubiquitination of Jak2
seems to be involved poteosomal degradation of p53/TP53
stimulated by adenovirus E1B-55 kD protein
may form a cell surface vasopressin receptor
protein modification; protein ubiquitination
neddylated. deneddylated via its interaction with the COP9 signalosome (CSN complex) (putative)
component of ECS(LRRC41) complex
component of ECS(SOCS1) complex
component of ECS(WSB1) complex
component of ECS(SOCS3) complex
component of ECS(SPSB1) complex
component of ECS(SPSB2) complex
component of ECS(SPSB4) complex
component of ECS(RAB40C) complex
may also form complexes containing CUL5, elongin BC complex (TCEB1 & TCEB2), RBX1 & TCEB3
may also form complexes containing CUL5, elongin BC (TCEB1 & TCEB2), RBX1 & VHL
the substrate recognition component can also be a viral protein such as HIV Vif, or human adenovirus 5 E1B large T-antigen & E4-orf6
interacts with RNF7/RBX2, LRRC41, SOCS3, SPSB1, SPSB2, SPSB4 & RAB40C
interacts with ASB1, ASB2, ASB6, ASB7 & ASB12

belongs to the cullin family