ankyrin repeat & SOCS box protein 6; ASB-6 (ASB6)

Function

• probable substrate-recognition component of an elongin-Cullin-SOCS-box protein (ECS) E3 ligase complex which mediates ubiquitination & subsequent proteasomal degradation of target proteins
• protein modification; protein ubiquitination
• binds AP
• identified in a complex with TCEB1 & TCEB2 (putative)
• interacts with CUL5 & RNF7

Structure

• the SOCS box domain mediates the interaction with the elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes (putative)
• contains 6 ANK repeats
• contains 1 SOCS box domain

Compartment

cytoplasm (putative)

Alternative splicing

named isoforms=2

More general terms

• Ankyrin repeat & SOCS box protein (ASB)

Additional terms

• Notch/ankyrin repeat
• SOCS box domain

Component of

• ECS complex; elonginB/C-CUL2/5-SOCS-box protein complex; ECS E3 ubiquitin-protein ligase complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=140459
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:140459
• UniProt: http://www.uniprot.org/uniprot/Q9NWX5.html