elongin B; elongin 18 kD subunit; transcription elongation factor B polypeptide 2; RNA polymerase II transcription factor SIII subunit B; SIII p18TCEB2 (EloB, TCEB2)

Function

• regulatory component of elongin
• component of elongin BC complex
• part of E3 ubiquitin ligase complexes with CUL5 or CUL2, RBX1 & a substrate adapter protein that can be either SOCS1, TCEB3, VHL or WSB1 (putative)
• substrate adapter protein can be a viral protein such as HIV Vif
• interacts with VHL protein modification; protein ubiquitination

Structure

contains 1 ubiquitin-like domain

Compartment

nucleus (probable)

More general terms

• protein subunit

Component of

• elongin (SIII, transcription elongation factor B, TEFB)
• elongin BC complex

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6923
• OMIM: https://mirror.omim.org/entry/600787
• UniProt: http://www.uniprot.org/uniprot/Q15370.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6923