ankyrin repeat & SOCS box protein 2; ASB-2 (ASB2)

Function

• probable substrate-recognition component of an elongin-Cullin-SOCS-box protein (ECS) E3 ligase complex which mediates the ubiquitination & subsequent proteasomal degradation of target proteins
• protein modification; protein ubiquitination
• component of the ECS(ASB2) complex

Structure

• the SOCS box domain mediates the interaction with the elongin BC complex (putative)
• contains 12 ANK repeats
• contains 1 SOCS box domain

Alternative splicing

named isoforms=2

Expression

• induced by all-trans retinoic acid (ATRA)

More general terms

• Ankyrin repeat & SOCS box protein (ASB)

Additional terms

• Notch/ankyrin repeat
• SOCS box domain

Component of

• ECS(ASB2) complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51676
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51676
• OMIM: https://mirror.omim.org/entry/605759
• UniProt: http://www.uniprot.org/uniprot/Q96Q27.html