all-trans retinoic acid; tretinoin (Retin-A, Renova, Avita, Altreno, ATRA)

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Introduction

Topical agent: Tradename: Retin-A, Avita. Systemic agent: ATRA.

Indications

Contraindications

* ref[4] adds that anticipated benefit should clearly outweigh any potential risk & that most dermatologists avoid using topical retinoids during pregnancy

pregnancy category = d

safety in lactation = ?

Dosage

Adverse effects

Mechanism of action

More general terms

Component of

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  3. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  4. Jump up to: 4.0 4.1 4.2 4.3 4.4 4.5 Medical Knowledge Self Assessment Program (MKSAP) 11, 16, 17. American College of Physicians, Philadelphia 1998, 2012, 2015.
  5. Jump up to: 5.0 5.1 UCLA Intensive Course in Geriatric Medicine & Board Review, Marina Del Ray, CA, Sept 12-15, 2001
  6. Department of Veterans Affairs, VA National Formulary
  7. Jump up to: 7.0 7.1 Weinstock MA et al Topical tretinoin therapy and all-cause mortality. Arch Dermatol 2009 Jan; 145:18. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19153339
    Schilling LM and Dellavalle RP Dealing with unanticipated mortality in a large randomized clinical trial of topical tretinoin. Arch Dermatol 2009 Jan; 145:76 PMID: https://www.ncbi.nlm.nih.gov/pubmed/19153348
  8. Jump up to: 8.0 8.1 Weinstock MA et al. Tretinoin and the prevention of keratinocyte carcinoma (basal and squamous cell carcinoma of the skin): A Veterans Affairs randomized chemoprevention trial. J Invest Dermatol 2012 Jun; 132:1583 PMID: https://www.ncbi.nlm.nih.gov/pubmed/22318383
  9. Jump up to: 9.0 9.1 Brooks M FDA Clears First Tretinoin Lotion for Acne (Altreno) Medscape - Aug 27, 2018. https://www.medscape.com/viewarticle/901240

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