neutrophilic dermatosis
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Introduction
Includes:
Etiology
- associated with
- chemotherapy
- penicillin for tonsillitis[3]
* 80-90% without underlying malignancy
Pathology
Clinical manifestations
- painful bullous lesions with a blue-gray border
- distribution: hands, arms, face
- painful lesions on the lip & soft palate
* images[3]
Laboratory
- complete blood count: WBC: 32K/uL, 88% neutrophils (case report)[3]
Management
- oral glucocorticoids
- oral cyclosporine
- wound care
* prognosis: may take > 1 years for all lesions to heal[3]
More general terms
More specific terms
References
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 15, 16, 17, 18. American College of Physicians, Philadelphia 2009, 2012, 2015, 2018.
- ↑ Dabade TS, Davis MD. Diagnosis and treatment of the neutrophilic dermatoses (pyoderma gangrenosum, Sweet's syndrome). Dermatol Ther. 2011 Mar-Apr;24(2):273-84 PMID: https://www.ncbi.nlm.nih.gov/pubmed/21410617
- ↑ 3.0 3.1 3.2 3.3 3.4 Moon JH, Huynh J Images in Clinical Medicine: Pathergy in Neutrophilic Dermatosis. N Engl J Med 2021; 384:271, JAn 21 https://www.nejm.org/doi/full/10.1056/NEJMicm1901738