anthracycline

^[1]^[2]^[3]

Adverse effects

irreversible dilated cardiomyopathy (2%), systolic heart failure directly related to cumulative dose
- increased risk of heart failure at 15 years after anthracycline 2-fold^[2]
cardiotoxicity synergistic with radiation therapy
atorvastatin reduces cardiac dysfunction in patients treated with anthracyclines^[3]

↑ Medical Knowledge Self Assessment Program (MKSAP) 15, 16, 17, 19. American College of Physicians, Philadelphia 2009, 2012, 2015, 2021
↑ ^2.0 ^2.1 Lou N Heart Failure Risk Lingers Long After Chemotherapy, Regardless of Dose. Several-fold higher cardiovascular risk of anthracycline use persists over two decades. MedPage Today February 3, 2023 https://www.medpagetoday.com/cardiology/chf/102955
Larsen CM, Garcia Arango M, Dasari H et al Association of Anthracycline With Heart Failure in Patients Treated for Breast Cancer or Lymphoma, 1985-2010. JAMA Netw Open. 2023;6(2):e2254669 PMID: https://www.ncbi.nlm.nih.gov/pubmed/36735254 Free article https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800936
↑ ^3.0 ^3.1 Neilan TG, Quinaglia T, Onoue T et al Atorvastatin for Anthracycline-Associated Cardiac Dysfunction. The STOP-CA Randomized Clinical Trial. JAMA. 2023;330(6):528-536. PMID: https://www.ncbi.nlm.nih.gov/pubmed/37552303 PMCID: PMC10410476 (available on 2024-02-08 https://jamanetwork.com/journals/jama/article-abstract/2807988