epirubicin; pidorubicin (Ellence)

Introduction

Tradename: Ellence.

Indications

• axillary node involvement after resection of breast cancer
• Hodgkin's disease
• diffuse large B-cell lymphoma
• gastric cancer
• osteosarcoma

Adverse effects

• cardiotoxicity -> heart failure

• drug adverse effects of anthracyclines

Mechanism of action

• anthracycline cytotoxic agent
  • 4' epimer of doxorubicin

More general terms

• anthracycline

Component of

• doxorubicin (Adriamycin, Rubex)
• cyclophosphamide/epirubicin/fluorouracil (CEF, FEC-100)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=41867
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=151537
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=497652