cyclophosphamide/epirubicin/fluorouracil (CEF, FEC-100)

Introduction

A chemotherapy regimen for adjuvant treatment of breast cancer.

Dosage

• CEF
  • cyclophosphamide 75 mg/m2 PO, days 1-14
  • epirubicin 60 mg/m2 IV, days 1 & 8
  • fluorouracil 500 mg/m2 IV, days 1 & 8
  • 28 day cycle x 4
• FEC-100
  • cyclophosphamide 500 mg/m2 PO, day 1
  • epirubicin 100 mg/m2 IV, day 1
  • fluorouracil 500 mg/m2 IV, day 1
  • 21 day cycle x 4

More general terms

• antineoplastic combination (combination chemotherapy)

Additional terms

• breast cancer

Components

• cyclophosphamide (Cytoxan, Neosar, Procytox {Canadian}) [CPM, CTX, CYT, NSC 26271]
• epirubicin; pidorubicin (Ellence)
• 5-fluorouracil [5-FU] (Fluoroplex, Efudex, Adrucel, Carac)