valrubicin (Valstar)

Indications

• bladder cancer
  • intravesical therapy of BCG-refractory carcinoma in situ of the urinary bladder
• cystectomy is not an option

Dosage

• 800 mg intravesically once a week for 6 weeks
• use four 5 mL single use vial 40 mg/mL (800 mg)
• dilute with 55 mL normal saline to a volume of 75 mL

Adverse effects

• urinary symptoms
  • urinary frequency, urgency
  • dysuria
  • urinary incontinence
  • hematuria

• drug adverse effects of anthracyclines

More general terms

• anthracycline