rab40c proto-oncogene protein; Ras-related protein Rab-40C; SOCS box-containing protein RAR3; Rar-like protein; Ras-like protein family member 8C (RAB40C, RARL, RASL8C)

Function

• probable substrate-recognition component of a SCF-like ECS (elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination & subsequent proteasomal degradation of target proteins
• component of the probable SCF-like ECS(RAB40C) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, elongin BC complex & RAB40C
• interacts with CUL5, RNF7, TCEB1 & TCEB2
• protein modification; protein ubiquitination

Structure

• the SOCS box domain mediates the interaction with the elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (putative)
• belongs to the small GTPase superfamily, Rab family
• contains 1 SOCS box domain

Compartment

• cell membrane; lipid-anchor; cytoplasmic side (putative)

More general terms

• rab40 proto-oncogene protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q96S21.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=57799