leucine-rich repeat-containing protein 41 (protein Muf1, LRRC41, MUF1, PP7759)

Function

• component of an E3 ubiquitin ligase complex with elongin BC complex (TCEB1 & TCEB2), RBX1 & CUL5
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• contains 7 LRR repeats (leucine-rich repeats)
• uncertain whether Met-1 or Met-23 is the initiator
• elongin BC complex binding domain is also known as BC- box with the consensus [APST]-L-x(3)-C-x(3)-[AILV]

Alternative splicing

named isoforms=3

More general terms

• leucine-rich repeat-containing protein (LRRC)
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q15345.html