ankyrin repeat & SOCS box protein 1; ASB-1 (ASB1, KIAA1146)

Function

• may play a role in testis development (putative)
• probable substrate-recognition component of an elongin-Cullin-SOCS-box protein (ECS) E3 ligase complex which mediates the ubiquitination & subsequent proteasomal degradation of target proteins
• protein modification; protein ubiquitination
• component of the ECS(ASB1) complex
• interacts with CUL5 & RNF7

Structure

• the SOCS box domain mediates interaction with the elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes (putative)
• contains 6 ANK repeats
• contains 1 SOCS box domain

More general terms

• Ankyrin repeat & SOCS box protein (ASB)

Additional terms

• Notch/ankyrin repeat
• SOCS box domain

Component of

• ECS(ASB1) complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51665
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51665
• OMIM: https://mirror.omim.org/entry/605758
• UniProt: http://www.uniprot.org/uniprot/Q9Y576.html