iodothyronine deiodinase type 2 (DIO2, ITDI2, TXDI2)

Function

• responsible for the deiodination of T4 into T3
• essential for providing brain with appropriate levels of T3 during the critical period of development

triiodothyronine + iodide + A + H+ <--> L-thyroxine + AH(2)

Structure

belongs to the iodothyronine deiodinase family

Alternative splicing

named isoforms=2

Expression

• heart, skeletal muscle, placenta, fetal brain & several regions of the adult brain

Pathology

• low activity associated with abnormal thyroid hormone metabolism phenotype

More general terms

• iodothyronine deiodinase
• membrane protein

Additional terms

• abnormal thyroid hormone metabolism (ATHYHM)
• thyrosine/iodothyronine [T4] deiodinase, iodide peroxidase or T3 synthase

Database

• OMIM: https://mirror.omim.org/entry/601413
• UniProt: http://www.uniprot.org/uniprot/Q92813.html