neddylation

Introduction

Conjugation of a target protein with ubiquitin-like protein NEDD8. The only known substrates for neddylation by NEDD8 are the cullins. Neddylation of cullins plays a role in recruitment of ubiquitin-conjugating protein-E2 to the multienzymatic ubiquitination complex.

Neddylation may play a role in:

• cell cycle regulation
• cytoskeletal regulation

More general terms

• protein conjugation

Additional terms

• NEDD8; ubiquitin-like protein Nedd8; neddylin; neural cell expressed developmentally down-regulated protein 8; NEDD-8 (NEDD8)