mediator of RNA polymerase II transcription subunit 8; activator-recruited cofactor 32 kD component; ARC32; mediator complex subunit 8 (MED8)

Function

• component of the mediator complex
• may play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes & thus in ubiquitination & subsequent proteasomal degradation of target proteins
• protein modification; protein ubiquitination
• component of an E3 ubiquitin-protein ligase complex with the elongin BC complex (TCEB1 & TCEB2), CUL2 & RBX1

Structure

• the elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV]
• belongs to the mediator complex subunit 8 family

Compartment

nucleus (probable)

Alternative splicing

named isoforms=3

More general terms

• transcription factor (TF)
• phosphoprotein

Component of

• activator-recruited cofactor (ARC)/DRIP
• mediator complex (mediator of RNA polymerase 2 transcription)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=112950
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:112950
• OMIM: https://mirror.omim.org/entry/607956
• UniProt: http://www.uniprot.org/uniprot/Q96G25.html