SKP1-CUL1-F-box protein (SCF) complex; SCF(FBXW11) E3 ligase complex; CF(SKP2) E3 ligase complex

Function

• mediates ubiquitination & subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction & transcription
• recognizes phosphorylated CDKN1B/p27kip & is involved in regulation of G1/S transition

Structure

• consists of CUL1, RBX1, SKP1, SKP2, FBXL (FBXL19, FBXL21, FBXW9, FBXW12)

More general terms

• SCF-type E3 ligase complex

Additional terms

• E3 ubiquitin ligase; ubiquitin-ligating enzyme E3; N end-recognizing protein