CDK2/cyclin A complex
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Function
- the CDK2/cyclin A complex affects regulation through S-phase
- CDK2 is expressed constitutively throughout the cell cycle
- association of CDK2 with cyclin A or cyclin E with subsequent dephosphorylation of Tyr15 & Thr14 on CDK2 by cdc25 phosphatase & an independently regulated phosphorylation of Thr160 activates CDK2
More general terms
References
- ↑ Xu et al Mol Cell Biol 14:8420 1004
- ↑ Cordon-Cardo C. Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia. Am J Pathol. 1995 Sep;147(3):545-60. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7677168
- ↑ Calbiochem Apoptosis catalog