M-phase inducer phosphatase or CDC25
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Function
- CDC25 phosphatases activate cell division kinases throughout the cell cycle
Comparative biology
- in fission yeast, drosophila, & humans, the product of CDC25 gene (p80cdc25 in humans & p54cdc25 in yeast) promotes G2 -> M transition via dephosphorylation of p34cdc2 (CDK1) in MPF or yeast equivalent[1]
More general terms
More specific terms
- M-phase inducer phosphatase-1 (dual-specificity phosphatase Cdc25A, CDC25A)
- M-phase inducer phosphatase-2 (dual specificity phosphatase Cdc25B, CDC25B, CDC25HU2)
- M-phase inducer phosphatase-3 (dual specificity phosphatase Cdc25C, CDC25C)
Additional terms
- cdc25 protein
- ras guanine nucleotide releasing factor 1; Ras-specific guanine nucleotide-releasing factor 1; Ras-GRF1; guanine nucleotide-releasing factor 1; Ras-specific nucleotide exchange factor CDC25 (RASGRF1, CDC25, GNRP, GRF1)
References
- ↑ 1.0 1.1 Strausfeld U et al Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein. Nature. 1991 May 16;351(6323):242-5. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1828290
- ↑ Gautier J, Solomon MJ, Booher RN, Bazan JF, Kirschner MW. cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2. Cell. 1991 Oct 4;67(1):197-211. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1913817
- ↑ Dunphy WG, Kumagai A. The cdc25 protein contains an intrinsic phosphatase activity. Cell. 1991 Oct 4;67(1):189-96. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1655274
- ↑ Keyse SM, Ginsburg M. Amino acid sequence similarity between CL100, a dual- specificity MAP kinase phosphatase and cdc25. Trends Biochem Sci. 1993 Oct;18(10):377-8. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8256285