cdc25 protein

From Aaushi
Jump to navigation Jump to search

Introduction

The cdc25 protein catalyzes guanine nucleotide exchange for the ras1 & ras2 proteins, activators of yeast adenylate cyclase. Some confusion here. In fission yeast, drosophila, & humans, the product of CDC25 gene (p54cdc25) promotes G2 -> M transition via dephosphorylation of p34cdc2 (CDK1) in MPF or yeast equivalent (ref 2)

More general terms

Additional terms

References

  1. Bourne HR et al Ras proteins, Some signal developments Nature 348:125 1990 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2175395
  2. Strausfeld U et al Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein. Nature. 1991 May 16;351(6323):242-5. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1828290
  3. Boguski MS & McCormick F Proteins regulating Ras and its relatives. Nature 366:643 1993 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8259209