cdc25 protein
Jump to navigation
Jump to search
Introduction
The cdc25 protein catalyzes guanine nucleotide exchange for the ras1 & ras2 proteins, activators of yeast adenylate cyclase. Some confusion here. In fission yeast, drosophila, & humans, the product of CDC25 gene (p54cdc25) promotes G2 -> M transition via dephosphorylation of p34cdc2 (CDK1) in MPF or yeast equivalent (ref 2)
More general terms
Additional terms
References
- ↑ Bourne HR et al Ras proteins, Some signal developments Nature 348:125 1990 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2175395
- ↑ Strausfeld U et al Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein. Nature. 1991 May 16;351(6323):242-5. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1828290
- ↑ Boguski MS & McCormick F Proteins regulating Ras and its relatives. Nature 366:643 1993 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8259209