M-phase inducer phosphatase-2 (dual specificity phosphatase Cdc25B, CDC25B, CDC25HU2)

Function

• tyrosine protein phosphatase
• dosage-dependent inducer of mitotic progression
• directly dephosphorylates CDC2 & stimulates its kinase activity
• the 3 isoforms seem to have a different level of activity
• stimulated by B-type cyclins
• phosphorylated by BRSK1 in vitro
• phosphorylated by CHEK1, which inhibits its activity

protein tyrosine phosphate + H2O <--> protein tyrosine + phosphate

Structure

• belongs to the MPI phosphatase family
• contains 1 rhodanese domain

Compartment

centrosome

Alternative splicing

named isoforms=4

More general terms

• M-phase inducer phosphatase or CDC25

Database

• UniProt: http://www.uniprot.org/uniprot/P30305.html
• OMIM: https://mirror.omim.org/entry/116949
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=994