serine/threonine protein kinase BRSK1; brain-specific serine/threonine protein kinase 1; BR serine/threonine protein kinase 1; serine/threonine protein kinase SAD-B; synapses of amphids defective homolog 1; SAD1 homolog; hSAD1 (BRSK1, KIAA1811, SAD1, SADB)

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Function

serine/threonine protein kinase
role in polarization of neurons & centrosome duplication
phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 & WEE1
following phosphorylation & activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule- associated proteins such as MAPT/TAU at Ser-579
also regulates neuron polarization by mediating phosphorylation of WEE1 at Ser-642 in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons
in neurons, localizes to synaptic vesicles & plays a role in neurotransmitter release, possibly by phosphorylating RIMS1
acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 & TUBG2) at Ser-131, leading to translocation of gamma-tubulin & its associated proteins to the centrosome
role in UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation & activation of WEE1, & inhibition of CDC25B & CDC25C
comment: would seem to both activate & inactivate WEE1
activated by phosphorylation on Thr-189 by STK11/LKB1
phosphorylated at Thr-189 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase & CAB39
not phosphorylated at Thr-189 by CaMKK2
in contrast, it is phosphorylated & activated by CaMKK
may be inactivated via dephosphorylation of Thr-189 by PP2C

belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily
contains 1 protein kinase domain
contains 1 UBA domain