regulating synaptic membrane exocytosis protein 1; Rab-3-interacting molecule 1; RIM 1; Rab-3-interacting protein 2 (RIMS1, KIAA0340, RAB3IP2, RIM1, Nbla00761)

Function

• Rab effector involved in exocytosis
• may act as scaffold protein that regulates neurotransmitter release at the active zone
• essential for maintaining normal probability of neurotransmitter release & for regulating release during short-term synaptic plasticity (putative)
• binds RAB3A, RAB3B & RAB3D that have been activated by GTP-binding
• binds UNC13A
• binds RIM-binding protein 1 & RIM-binding protein 2
• interacts with PPFIA3 & PPFIA4 (putative)
• binds SNAP25, SYT1 & CACNA1B
• interaction with SYT1 is enhanced by Ca+2
• interaction with SNAP25 is weaker in the presence of Ca+2

Structure

• contains 2 C2 domains
• contains 1 FYVE-type Zn+2 finger
• contains 1 PDZ domain (DHR domain)
• contains 1 RabBD (Rab-binding) domain

Compartment

• cell membrane, peripheral membrane (putative)
• cell junction, synapse
• cell junction, synapse, presynaptic cell membrane

Alternative splicing

• named isoforms=8
• additional isoforms seem to exist
• at least one isoform may be due to intron retention

Expression

detected in brain & retina

Pathology

• defects in RIMS1 may be a cause of cone-rod dystrophy type 7

More general terms

• Rab3-interacting molecule
• zinc finger protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=22999
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:22999
• OMIM: https://mirror.omim.org/entry/603649
• OMIM: https://mirror.omim.org/entry/606629
• UniProt: http://www.uniprot.org/uniprot/Q86UR5.html