Zn finger Fyve-type

Introduction

The FYVE domain is named for the first 4 proteins in which it was found (Fab1, YOTB/ZK632.12, Vac1, & EEA1). It is a cysteine-rich region of about 70 amino acid resides with 8 conserved Cys coordinating two Zn2+ ions.

The FYVE domain is found in eukaryotic non-nuclear proteins involved in vesicle transport, signal transduction & cytoskeletal regulation. The FYVE domain targets signal-transducing proteins to cell membranes through binding to the membrane lipid phosphatidylinositol-3-phosphate (PtdIns(3)P.

Generally, only one copy of the FYVE domain is present.

The FYVE-related domain is found in several proteins involved in regulated secretion, such as Rabphilin-3A & Rim. Although the structure of the FYVE-related domain is closely related to the genuine FYVE domain, the FYVE-related domain lacks several of the conserved features of the FYVE domain, & it does not bind to PtdIns(3)P.

More general terms

• Zinc finger (cysteine finger)