early endosome antigen 1; endosome-associated protein p162; zinc finger FYVE domain-containing protein 2 (EEA1, ZFYVE2)

Function

• binds phospholipid vesicles containing phosphatidylinositol 3-phosphate & participates in endosomal trafficking
• homodimer
• binds STX6
• binds RAB5A, RAB5B, RAB5C & RAB22A that have been activated by GTP-binding

Structure

• the FYVE-type Zn+2 finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes & penetrates bilayers
• the FYVE domain insertion into Ptdins(3)P-enriched membranes is substantially increased in acidic conditions
• contains 1 C2H2-type Zn+2 finger
• contains 1 FYVE-type Zn+2 finger

Compartment

• cytoplasm
• early endosome membrane, peripheral membrane

Pathology

• antibodies against EEA1 are found in sera from patients with subacute cutaneous lupus erythematosus & other autoimmune diseases

More general terms

• C2H2 type zinc finger protein
• zinc finger FYVE domain-containing protein (ZFYVE)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8411
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8411
• OMIM: https://mirror.omim.org/entry/605070
• UniProt: http://www.uniprot.org/uniprot/Q15075.html