rab5b proto-oncogene protein; Ras-related protein Rab-5B (RAB5B)

Function

• plasma membrane-early endosome transport
• early endosome fusion & mobility
• regulated by guanine nucleotide exchange factors (GEFs) which promote exchange of bound GDP for free GTP
• binds EEA1
• interacts with RIN2 & RIN3, which probably regulates its pathway, possibly by acting as GEFs

Structure

• belongs to the small GTPase superfamily, Rab family

Compartment

• cell membrane; lipid-anchor; cytoplasmic side
• early endosome membrane; lipid-anchor
• melanosome; enriched in stage I melanosomes

More general terms

• rab5 proto-oncogene protein

Database

• UniProt: http://www.uniprot.org/uniprot/P61020.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5869
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5869
• OMIM: https://mirror.omim.org/entry/179514