Ras & Rab interactor 3; Ras interaction/interference protein 3 (RIN3)

Function

• potential Ras effector protein
• may function as a guanine nucleotide exchange (GEF), by exchanging bound GDP for free GTP
• interacts with RAB5B & BIN1

Structure

• belongs to the RIN (Ras interaction/interference) family
• contains 1 Ras-associating domain
• contains 1 SH2 domain
• contains 1 VPS9 domain

Compartment

• cytoplasm, cytoplasmic vesicle, early endosome
• activation of Tyr phosphorylation signaling induces translocation to cytoplasmic vesicles

Alternative splicing

named isoforms=4

Expression

widely expressed

More general terms

• Ras & Rab interactor

Additional terms

• rab subfamily protein
• ras subfamily protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=79890
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:79890
• OMIM: https://mirror.omim.org/entry/610223
• UniProt: http://www.uniprot.org/uniprot/Q8TB24.html