peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1, peripheral benzodiazepine receptor-interacting protein, PBR-IP, RIM-binding protein 1, RIM-BP1, BZRAP1, KIAA0612, RBP1)

Function

• interacts with RIMS1 & RIMS2
  • 2nd SH3 domain mediates binding to a proline-rich motif in RIMS1 & RIMS2
• interacts with BZRP
  • SH3 & proline-rich domain mediates interaction with BZRP

Structure

• SH3 domain & proline-rich domain required for interaction with BZRP
• 2nd SH3 domain mediates binding to a proline-rich motif in RIMS1 and RIMS2

Compartment

• cytoplasm, mitochondria
• preferentially localizes to mitochondria in the presence of BZRP

Alternative splicing

named isoforms=3

Expression

• predominantly expressed in brain, pituitary gland, thymus in adult
• in brain adult, expressed in temporal lobe, putamen > amygdala, caudate nucleus, cerebral cortex, occipital, frontal lobe
• high expression level in fetal brain, heart, kidney & thymus

More general terms

• other protein

Database

• UniProt: http://www.uniprot.org/uniprot/O95153.html