regulating synaptic membrane exocytosis protein 2; Rab-3-interacting molecule 2; RIM 2; Rab-3-interacting protein 3 (RIMS2, KIAA0751, RAB3IP3, RIM2)

Function

• Rab effector involved in exocytosis
• may act as scaffold protein
• binds GTP-activated RAB3A & RAB3B
• heterodimer with PCLO
• part of a ternary complex involving PCLO & EPAC2
• binds RIM-binding protein 1 & RIM-binding protein 2
• interacts with PPFIA3 & PPFIA4
• interacts via its Zn+2 fingerwith the first C2 domain of UNC13A
• forms a complex consisting of UNC13A, RIMS2 & RAB3A (putative)

Structure

• contains 2 C2 domains
• contains 1 FYVE-type Zn+2 finger
• contains 1 PDZ domain (DHR domain)
• contains 1 RabBD (Rab-binding) domain

Compartment

• cell membrane; peripheral membrane (putative)
• cell junction, synapse, presynaptic cell membrane

Alternative splicing

• named isoforms=7
• several isoforms may be due to intron retention

More general terms

• Rab3-interacting molecule
• zinc finger protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9699
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9699
• OMIM: https://mirror.omim.org/entry/606630
• UniProt: http://www.uniprot.org/uniprot/Q9UQ26.html