protein piccolo; Aczonin (PCLO ACZ KIAA0559)

Function

• may act as a scaffolding protein involved in the organization of synaptic active zones & in synaptic vesicle trafficking
• interacts with Rabac1/Pra1, RIMS2 & profilin

Structure

• C2 domain 1 is involved in binding Ca+2 & phospholipids
  • Ca+2 binds with low affinity but with high specificity & induces a large conformational change
• contains 2 C2 domains
• contains 1 PDZ domain (DHR domain)

Compartment

• cell junction, synapse (putative)
• concentrated at the presynaptic side of synaptic junctions

Alternative splicing

• named isoforms=3
• additional isoforms seem to exist

More general terms

• zinc finger protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=27445
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:27445
• OMIM: https://mirror.omim.org/entry/604918
• UniProt: http://www.uniprot.org/uniprot/Q9Y6V0.html