prenylated Rab acceptor protein 1 (PRA1 family protein 1, RABAC1, PRA1, PRAF1)

Function

• Rab protein regulator required for vesicle formation from Golgi complex
• may control vesicle docking & fusion by mediating the action of Rab GTPases to SNARE complexes
• inhibits removal of Rab GTPases from membrane by GDI
• interacts with VAMP2 (synaptobrevin-2), GDI1, & PCLO
• interacts specifically with prenylated Rab proteins, strongly with RAB4B, RAB5A and RAB5C, & weakly with RAB4A, RAB6, RAB7, RAB17 & RAB22
• contrast to the mouse ortholog, does not interact with Ras

Structure

• homodimer
• belongs to the PRA1 family

Compartment

• cell membrane, cytoplasm, Golgi, cytoplasmic vesicle, secretory vesicle, synaptic vesicle

Expression

• ubiquitous
• strongest expression found in placenta, pituitary gland, kidney, lung & stomach
• in fetal tissues, more abundant in kidney & lung

More general terms

• transmembrane 4 protein

Database

• OMIM: https://mirror.omim.org/entry/604925
• UniProt: http://www.uniprot.org/uniprot/Q9UI14.html