synaptobrevin-2; vesicle-associated membrane protein 2; VAMP-2; SCN2 protein (VAMP2, SYB2)
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Function
- probably functions in the exocytotic fusion of synaptic vesicles
- role in the targeting &/or fusion of transport vesicles to their target membrane
- interacts with VAPA & VAPB
- synaptobrevin-2 is the proteolytic target of tetanus toxin & botulinum-B toxin
Structure
- belongs to the synaptobrevin family
- contains 1 v-SNARE coiled-coil homology domain
Compartment
- cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
- cell junction, synapse, synaptosome
- neuronal synaptic vesicles
Expression
nervous system & skeletal muscle
More general terms
Additional terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P63027.html
- ↑ Sollner T, Whiteheart SW, Brunner M et al SNAP receptors implicated in vesicle targeting and fusion. Nature. 1993 Mar 25;362(6418):318-24. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8455717
- ↑ Barinaga M. Secrets of secretion revealed. Science. 1993 Apr 23;260(5107):487-9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8475382