tetanus toxin (TeTx); tetanospasmin

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[1][2]

Introduction

Zinc metalloprotease specific for synaptobrevin-2.

Inhibitor of neurotransmitter release.

Tetanospasmin is produced as a single chain polypeptide in vegetative cells under plasmid control. With autolysis, tetanospasm is cleaved to form a disulfide-linked heterodimer with subunits of MW 100 kD & 50 kD. Tetanus & botulinum toxins are the two most powerful neurotoxins known.

More general terms

References

  1. ↑ Sollner T, Whiteheart SW, Brunner M et al SNAP receptors implicated in vesicle targeting and fusion. Nature. 1993 Mar 25;362(6418):318-24. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8455717
  2. ↑ Harrison's Principles of Internal Medicine, 13th ed. Isselbacher et al (eds), McGraw-Hill Inc. NY, 1994, pg 633
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