vesicle-associated membrane protein-associated protein B/C (VAMP-associated protein B/C, VAMP-B/VAMP-C, VAP-B/VAP-C, VAPB)

Function

• vesicle trafficking
• homodimer, & heterodimer with VAPA
• interacts with VAMP1 & VAMP2

Compartment

plasma membrane, intracellular vesicles

Alternative splicing

named isoforms=2

Expression

• ubiquitous
• isoform 1 predominates

Pathology

• defects in VAPB cause amyotrophic lateral sclerosis 8 (ALS8)

More general terms

• membrane protein

Database

• OMIM: https://mirror.omim.org/entry/605704
• OMIM: https://mirror.omim.org/entry/608627
• UniProt: http://www.uniprot.org/uniprot/O95292.html