synaptobrevin-1; vesicle-associated membrane protein 1; VAMP-1; SCN1 protein (VAMP1, SYB1)

Function

• probably functions in the exocytotic fusion of synaptic vesicles
• role in the targeting &/or fusion of transport vesicles to their target membrane
• interacts with VAPA & VAPB

Structure

• belongs to the synaptobrevin family
• contains 1 v-SNARE coiled-coil homology domain

Compartment

• isoform 1:
  • cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
  • cell junction, synapse, synaptosome
• isoform 2:
  • cytoplasmic vesicle membrane
• isoform 3: outer mitochondrial membrane

Alternative splicing

named isoforms=3

Expression

nervous system, skeletal muscle & adipose tissue

More general terms

• synaptobrevin or vesicle-associated membrane protein (VAMP)
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6843
• OMIM: https://mirror.omim.org/entry/185880
• UniProt: http://www.uniprot.org/uniprot/P23763.html