Rab GDP dissociation inhibitor alpha; Rab GDI alpha; guanosine diphosphate dissociation inhibitor 1; GDI-1; oligophrenin-2; protein XAP-4 (GDI1, GDIL, OPHN2, RABGDIA, XAP4)

Function

• regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, & the subsequent binding of GTP to them
• interacts with RHOH

Structure

belongs to the Rab GDI family

Compartment

cytoplasm (putative)

Expression

• brain
• predominant in neural & sensory tissues

Pathology

• defects in GDI1 are the cause of mental retardation X-linked type 41

More general terms

• rab GDP dissociation inhibitor
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2664
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2664
• OMIM: https://mirror.omim.org/entry/300104
• UniProt: http://www.uniprot.org/uniprot/P31150.html