rab GDP dissociation inhibitor, smg p25A GDP dissociation inhibitor or rab3A GDP dissociation inhibitor (rab3A-GDI)

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Introduction

Inhibits dissociation of GDP from rab proteins. Solubilizes membrane-associated rab9-GDP. rab GDI may only recognize prenylated forms of rab subfamily proteins[5].

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References

  1. Bourne HR et al, The GTPase superfamily: a conserved switch for diverse cell functions Nature 348:125 1990 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2122258
  2. Matsui Y et al Molecular cloning and characterization of a novel type of regulatory protein (GDI) for smg p25A, a ras p21-like GTP- binding protein. Mol Cell Biol 1990 Aug;10(8):4116-22 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2115118
  3. Soldati T et al Rab GDI: a solubilizing and recycling factor for rab9 protein. Mol Biol Cell 4:425 1993 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8389620
  4. Ullrich O et al Rab GDP dissociation inhibitor as a general regulator for the membrane association of rab proteins J Biol Chem 268:18143 1993 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8349690
  5. 5.0 5.1 Boguski MS & McCormick F Proteins regulating Ras and its relative. Nature 366:643 1993 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8259209