rab4a proto-oncogene protein; Ras-related protein Rab-4A (RAB4A, RAB4)
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Function
- protein transport.
- probably involved in vesicular traffic (putative)
- early endosome-plasma membrane sorting & recycling
- phosphorylated by CDC2 kinase during mitosis
- interacts with RAB11FIP1, RABEP1, ZFYVE20 & RUFY1
- interacts with SGSM1, SGSM2 & SGSM3 (putative)
Structure
belongs to the small GTPase superfamily, Rab family
Compartment
- membrane; peripheral membrane protein
- cytoplasm
- generally associated with membranes
- cytoplasmic when phosphorylated by CDC2
More general terms
References
- ↑ Bailly E, McCaffrey M, Touchot N, Zahraoui A, Goud B, Bornens M. Phosphorylation of two small GTP-binding proteins of the Rab family by p34cdc2. Nature. 1991 Apr 25;350(6320):715-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1902553
- ↑ Seabra MC et al Rab GTPases, intracellular traffic and disease Trends in Molecular Medicine 8:23, 2002 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11796263
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5867
- ↑ UniProt http://www.uniprot.org/uniprot/P20338.html