Rab GTPase-binding effector protein 1; rabaptin-4; rabaptin-5; rabaptin-5alpha; renal carcinoma antigen NY-REN-17 (RABEP1, RAB5EP, RABPT5, RABPT5A)

Function

• Rab effector protein, links gamma-adaptin, RAB4A & RAB5A
  • binds RAB4A & RAB5A activated by GTP
• endocytic membrane fusion & membrane trafficking of recycling endosomes
• stimulates RABGEF1 mediated nucleotide exchange on RAB5A
• binds TSC2, GGA1, GGA2, GGA3, AP1G1, AP1G2
• homodimer when bound to RAB5A
• heterodimer with RABGEF1
  • heterodimer binds RAB4A & RAB5A activated by GTP-binding
• proteolytic cleavage by caspases in apoptotic cells results in loss of endosome fusion activity
• interacts with ECM29

Structure

belongs to the rabaptin family

Compartment

• cytoplasm
• early endosome, recycling endosome
• cytoplasmic vesicle

Alternative splicing

named isoforms=2

More general terms

• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/603616
• UniProt: http://www.uniprot.org/uniprot/Q15276.html