Rab5 GDP/GTP exchange factor; RAP1; Rabaptin-5-associated exchange factor for Rab5; Rabex-5 (RABGEF1, RABEX5)

Function

• Rab effector protein
• acts as linker between gamma-adaptin, RAB4A or RAB5A
• endocytic membrane fusion
• membrane trafficking of recycling endosomes
• stimulates nucleotide exchange on RAB5A
• can act as a ubiquitin ligase (putative)
• monoubiquitinated
• heterodimer with RABEP1; heterodimer binds RAB4A & RAB5A (activated by GTP-binding)
• binds TSC2, GGA1, GGA2, GGA3, AP1G1 & AP1G2
• interacts with RGS14 (GTP-dependent)
• interacts with RAB21 with RAB22
• interacts with ubiquitinated EGFR

Structure

• contains 1 A20-type Zn+2 finger
• contains 1 VPS9 domain

Compartment

cytoplasmic, early & recycling endosomes

Alternative splicing

named isoforms=3

More general terms

• zinc finger protein
• protein subunit
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=27342
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:27342
• OMIM: https://mirror.omim.org/entry/609700
• UniProt: http://www.uniprot.org/uniprot/Q9UJ41.html