tumor necrosis factor, alpha-induced protein 3; DNA-binding protein A20; zinc finger protein A20 (TNFAIP3)

Function

• interacts with NAF1
• inhibits TNF-induced NF-kappa-B-dependent gene expression by interfering with RIP- or TRAF2-mediated transactivation
• inhibitor of programmed cell death.
• function of the lymphoid system
  • modulates in vivo effects of TNF
  • induced by TNF-alpha
• deubiquitinating activity directed towards Lys-48 or Lys-63-linked polyubiquitin chains
• homodimer
• interacts with NAF1, TAX1BP1, TRAF2

Structure

• belongs to the peptidase C64 family
• contains 7 A20-type zinc fingers
  • contains 1 OTU domain

Compartment

cytoplasm, nucleus

Expression

induced by TNF-alpha

Pathology

• deletions associated with constitutive activation of NF-kappa B in diffuse large B-cell lymphoma (DLBCL)

More general terms

• DNA-binding protein
• zinc finger protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7128
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7128
• OMIM: https://mirror.omim.org/entry/191163
• UniProt: http://www.uniprot.org/uniprot/P21580.html