Tax1-binding protein 1 (TRAF6-binding protein, TAX1BP1, T6BP, PRO0105)

Function

• inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity
• degraded by caspase-3-like family proteins upon TNF-induced apoptosis
• role in pro-inflammatory cytokine IL-1 signaling
• interacts with TRAF6 (IL-1-dependent)
• interacts with TNFAIP3 & STARD13

Structure

homooligomer

Alternative splicing

named isoforms=3

Expression

expressed in all tissues tested

More general terms

• other protein

Database

• OMIM: https://mirror.omim.org/entry/605326
• UniProt: http://www.uniprot.org/uniprot/Q86VP1.html