StAR-related lipid transfer protein 13; 46H23.2; deleted in liver cancer 2 protein; DLC-2; START domain-containing protein 13; StARD13 (STARD13, DLC2, GT650)

Function

• GTPase-activating protein for RhoA, & perhaps for Cdc42
• may be involved in regulation of cytoskeletal reorganization, cell proliferation & cell motility
• acts as s tumor suppressor in hepatocellular carcinoma cells
• homodimer
• interacts with TAX1BP1

Structure

• contains 1 Rho-GAP domain
• contains 1 SAM (sterile alpha motif) domain
• contains 1 START domain

Compartment

• cytoplasm
• peripheral membrane, cytoplasmic side
• mitochondrial membrane
• lipid droplet

Alternative splicing

named isoforms=5

Expression

• ubiquitously expressed

Pathology

• underexpressed in hepatocellular carcinoma cells & some breast cancer cell lines

More general terms

• StAR-related lipid transfer protein
• rho GTPase-activating protein (rho-GAP)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=90627
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:90627
• OMIM: https://mirror.omim.org/entry/609866
• UniProt: http://www.uniprot.org/uniprot/Q9Y3M8.html