gamma-2 adaptin; AP-1 complex subunit gamma-like 2; G2ad (AP1G2)

Function

• does not appear to be a subunit of the clathrin-associated adaptor protein complex 1 (AP-1)
• may function in protein sorting in late endosomes or multivesucular bodies
• probably interacts with AP1S1/sigma1A-adaptin & AP1S2/sigma1B-adaptin
• probably does not interact with beta-adaptin APB1
• binds ubiquitin

Structure

• belongs to the adaptor complexes large subunit family
• contains 1 GAE domain

Compartment

• Golgi membrane, peripheral membrane
• cytoplasmic vesicle membrane, endosome membrane
• mainly localized to perinuclear vesicular structures

Expression

• expressed in all tissues examined, except skeletal muscle

Pathology

• role in multivesucular body-assisted maturation of hepatitis B virus
• interacts with HBV major surface antigen L
• interacts with HBV core protein C (ubiquitin-dependent)
• colocalizes with HBV major surface antigen L & HBV core protein C in CD63-containing compartments
• colocalizes with HBV major surface antigen L to cis-Golgi-like structures

More general terms

• gamma adaptin (adaptor-related protein complex, gamma subunit)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8906
• OMIM: https://mirror.omim.org/entry/603534
• UniProt: http://www.uniprot.org/uniprot/O75843.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8906